|
NEUROCRINE BIOSCIENCES INC
|
3,366,530
|
$145,771,000
|
8.30%
|
+50,007
|
+$17,422,000
|
|
Global Blood Therapeutics, Inc.
|
3,858,978
|
$142,203,000
|
8.10%
|
+730,000
|
+$96,990,000
|
|
AMICUS THERAPEUTICS, INC.
|
17,296,672
|
$123,325,000
|
7.03%
|
No Change
|
+$37,361,000
|
|
VERSARTIS SHARES
|
4,407,317
|
$94,096,000
|
5.36%
|
+253,632
|
+$32,207,000
|
|
LA JOLLA PHARMACEUTICAL CO
|
2,139,274
|
$63,857,000
|
3.64%
|
+820,000
|
+$40,730,000
|
|
ALNYLAM PHARMACEUTICALS, INC.
|
1,103,475
|
$56,553,000
|
3.22%
|
+985,000
|
+$52,117,000
|
|
Sarepta Therapeutics, Inc.
|
1,771,029
|
$52,422,000
|
2.99%
|
-998,800
|
-$23,554,000
|
|
Retrophin, Inc.
|
2,807,525
|
$51,826,000
|
2.95%
|
+120,113
|
+$954,000
|
|
NxStage Medical, Inc.
|
1,818,189
|
$48,782,000
|
2.78%
|
-109,800
|
-$1,751,000
|
|
Xencor Inc
|
1,607,018
|
$38,440,000
|
2.19%
|
-178,000
|
-$8,542,000
|
|
Aclaris Therapeutics, Inc.
|
1,260,847
|
$37,598,000
|
2.14%
|
No Change
|
+$3,379,000
|
|
Tesaro Inc
|
241,028
|
$37,087,000
|
2.11%
|
-446,965
|
-$55,434,000
|
|
VBI Vaccines Inc/BC
|
6,565,843
|
$36,046,000
|
2.05%
|
No Change
|
+$15,692,000
|
|
Radius Health, Inc.
|
910,872
|
$35,205,000
|
2.01%
|
+647,000
|
+$25,170,000
|
|
AVEXIS SHARES
|
448,501
|
$34,100,000
|
1.94%
|
-25,030
|
+$11,498,000
|
|
Evolent Health, Inc.
|
1,444,500
|
$32,212,000
|
1.83%
|
+1,136,700
|
+$27,657,000
|
|
VERTEX PHARMACEUTICALS INC / MA
|
293,509
|
$32,095,000
|
1.83%
|
+208,000
|
+$25,796,000
|
|
REGENXBIO Inc.
|
1,396,244
|
$26,947,000
|
1.54%
|
+113,958
|
+$3,161,000
|
|
LION BIOTECHNOLOGIES SHARES
|
3,567,553
|
$26,578,000
|
1.51%
|
No Change
|
+$1,784,000
|
|
CytomX Therapeutics, Inc.
|
1,530,659
|
$26,434,000
|
1.51%
|
+606,896
|
+$16,282,000
|
|
ANAPTYSBIO, INC
|
881,957
|
$24,474,000
|
1.39%
|
New
|
+$24,474,000
|
|
ZOGENIX, INC.
|
2,203,302
|
$23,906,000
|
1.36%
|
+1,450,303
|
+$14,757,000
|
|
ARDELYX, INC.
|
1,886,196
|
$23,860,000
|
1.36%
|
+50,000
|
-$2,213,000
|
|
GALAPAGOS NV
|
271,405
|
$23,392,000
|
1.33%
|
-33,126
|
+$2,761,000
|
|
DBV Technologies S.A.
|
591,765
|
$20,842,000
|
1.19%
|
-18,878
|
-$610,000
|